A Question was asked on Stack Overflow and it got me thinking, could the OP use aria-label ?

Turns out you can:

<span aria-label="Uppercase A">A</span>
<span aria-label="Lowercase l">l</span>
<span aria-label="3">3</span>
<span aria-label="lowercase x">x</span>

Renders the following: A l 3 x

Try listening with a screen reader, or voice assistant on your mobile, cool huh?!